Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 11/20 | 0.40 |
| ▸ | LPL | P06858 | 10/20 | 0.40 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | LAP3 | P28838 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24299234 | 0.90 | CXCR2 (0.40) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL29457774 | 0.90 | CXCR2 (0.40) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL30737822 | 0.86 | LPL (0.42) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL15810486 | 0.86 | LPL (0.42) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL15780082 | 0.84 | LIPG (0.50) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL16077614 | 0.81 | LIPG (0.47) | CXCR2LIPGLPL | |
| SCHEMBL902458 | 0.81 | LIPG (0.49) | CXCR2LIPGLPLF11P4HB | |
| SCHEMBL13202078 | 0.80 | LPL (0.43) | CXCR2LIPGLPLP4HBANPEP | |
| SCHEMBL29543244 | 0.80 | CXCR2 (0.40) | CXCR2LIPGLPLANPEPLAP3 | |
| SCHEMBL23295322 | 0.80 | CXCR2 (0.40) | CXCR2LIPGLPLANPEPLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |