Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | PGR | P06401 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5536182 | 0.81 | VEGFA (0.68) | MAPTMEN1KMT2ANPSR1HTT | |
| Clemizole SCHEMBL19976081 | 0.80 | HIF1A (0.84) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| Clemizole SCHEMBL19976085 | 0.80 | HIF1A (0.88) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| SCHEMBL11749672 | 0.80 | HIF1A (0.79) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| Clemizole SCHEMBL19976078 | 0.79 | HIF1A (0.86) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| Clemizole SCHEMBL19976082 | 0.79 | HIF1A (0.80) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| SCHEMBL15568741 | 0.79 | ALDH1A1 (0.63) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| Clemizole SCHEMBL29403196 | 0.78 | HIF1A (1.00) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| Clemizole SCHEMBL29938 | 0.78 | HIF1A (1.00) | HIF1ATDP1LMNACYP1A2CYP2D6 | |
| SCHEMBL15568517 | 0.78 | ALDH1A1 (0.69) | HIF1ATDP1LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220226508-A1 | METHODS AND COMPOSITIONS FOR TREATING EPILEPSY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-07-21 | — | — | US | disclosed |
| EP-3976187-A1 | METHODS AND COMPOSITIONS FOR TREATING EPILEPSY | The Regents of the University of California (US) | 2022-04-06 | — | — | EP | disclosed |
| CN-114007692-A | Methods and compositions for treating epilepsy | 加利福尼亚大学董事会 | 2022-02-01 | — | — | CN | disclosed |
| WO-2020243349-A1 | METHODS AND COMPOSITIONS FOR TREATING EPILEPSY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220226508-A1 | METHODS AND COMPOSITIONS FOR TREATING EPILEPSY | HTR2B, HTR3B, HTR1B | HIF1A 2361/4885TDP1 3912/4885LMNA 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.