Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27833091 | 0.92 | KDM5A (0.39) | KDM5AKDM5BMAOBMRGPRX4PIK3CA | |
| SCHEMBL15746652 | 0.90 | MAOB (0.38) | KDM5AKDM5BMAOBMRGPRX4EGLN1 | |
| SCHEMBL1503109 | 0.90 | HDAC1 (0.47) | KDM5AKDM5BMAOBPIK3CAHDAC3 | |
| SCHEMBL4304503 | 0.85 | PPARG (0.41) | MAOBMRGPRX4NPC1RAB9AMAPT | |
| SCHEMBL15746657 | 0.84 | KDM4E (0.41) | KDM5AKDM5BMAOB | |
| SCHEMBL15746685 | 0.80 | ALKBH1 (0.42) | KDM5AKDM5BMAOB | |
| SCHEMBL27833092 | 0.80 | RNASEH1 (0.38) | KDM5AKDM5BMAOBMRGPRX4PIK3CA | |
| SCHEMBL22719946 | 0.80 | GAA (0.44) | HDAC3HDAC1HDAC2HDAC6RAB9A | |
| SCHEMBL1503156 | 0.80 | LRRK2 (0.37) | KDM5AKDM5BMAOBHDAC3HDAC1 | |
| SCHEMBL1503208 | 0.78 | MAOB (0.40) | KDM5AKDM5BMAOBMRGPRX4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146555-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | AMBRILIA BIOPHARMA INC. (CA) | 2009-12-10 | — | — | WO | claimed |
| US-8742123-B2 | HIV integrase inhibitors from pyridoxine | TAIMED BIOLOGICS, INC. (TW) | 2014-06-03 | — | — | US | disclosed |