Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719912 | 0.89 | KMT2A (0.39) | LMNATSHRGABRA5ALDH1A1MAPK1 | |
| SCHEMBL30193078 | 0.87 | KMT2A (0.40) | GABRA5ALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL1503189 | 0.87 | KMT2A (0.40) | GABRA5ALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL22719899 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPK1KMT2A | |
| SCHEMBL22719921 | 0.78 | NPY5R (0.39) | NTRK1 | |
| SCHEMBL22283910 | 0.78 | ALDH1A1 (0.59) | ALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL22738226 | 0.77 | SCN9A (0.38) | ALDH1A1MAPK1KMT2A | |
| SCHEMBL22738228 | 0.77 | TRPV1 (0.39) | NTRK1 | |
| SCHEMBL22719897 | 0.77 | ALDH1A1 (0.41) | LMNAALDH1A1MAPK1KMT2AGAA | |
| SCHEMBL22719962 | 0.77 | KMT2A (0.41) | LMNAALDH1A1MAPK1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |