Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 7/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 4/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22719897 | 0.89 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPK1MAOBGAA | |
| SCHEMBL22283910 | 0.84 | ALDH1A1 (0.59) | KMT2AALDH1A1MAPK1MAOBGAA | |
| SCHEMBL30193078 | 0.81 | KMT2A (0.40) | KMT2AALDH1A1MAPK1MAOBGAA | |
| SCHEMBL1503189 | 0.81 | KMT2A (0.40) | KMT2AALDH1A1MAPK1MAOBGAA | |
| SCHEMBL22719910 | 0.81 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPK1MAOBGAA | |
| SCHEMBL22719912 | 0.80 | KMT2A (0.39) | KMT2AALDH1A1MAPK1MAOBGAA | |
| SCHEMBL22719947 | 0.77 | LMNA (0.46) | KMT2AALDH1A1MAPK1GAALMNA | |
| SCHEMBL3442472 | 0.72 | KMT2A (0.57) | KMT2AALDH1A1MAPK1MAOBMAPT | |
| SCHEMBL22719950 | 0.71 | MAOB (0.39) | KMT2AALDH1A1MAPK1MAOBLMNA | |
| SCHEMBL1503147 | 0.69 | ALDH1A1 (0.39) | KMT2AALDH1A1MAPK1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |