Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193078 | 0.90 | KMT2A (0.40) | KMT2AALDH1A1MAPK1GAAMAOB | |
| SCHEMBL1503189 | 0.90 | KMT2A (0.40) | KMT2AALDH1A1MAPK1GAAMAOB | |
| SCHEMBL22719947 | 0.89 | LMNA (0.46) | KMT2AALDH1A1MAPK1GAALMNA | |
| SCHEMBL22738226 | 0.87 | SCN9A (0.38) | KMT2AALDH1A1MAPK1MAOBMAPT | |
| SCHEMBL22283910 | 0.81 | ALDH1A1 (0.59) | KMT2AALDH1A1MAPK1GAAMAOB | |
| SCHEMBL22719962 | 0.80 | KMT2A (0.41) | KMT2AALDH1A1MAPK1GAAMAOB | |
| SCHEMBL22719897 | 0.80 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPK1GAAMAOB | |
| SCHEMBL22719950 | 0.80 | MAOB (0.39) | KMT2AALDH1A1MAPK1MAOBLMNA | |
| SCHEMBL2147314 | 0.79 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPK1MAOBPOLB | |
| SCHEMBL22719910 | 0.78 | ALDH1A1 (0.41) | KMT2AALDH1A1MAPK1GAAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020237374-A1 | PICOLINIC ACID DERIVATIVES AND USE THEREOF FOR TREATING DISEASES ASSOCIATED WITH ELEVATED CHOLESTEROL | MONTREAL HEART INSTITUTE (CA) | 2020-12-03 | — | — | WO | disclosed |