Chalcone

Chalcone

SCHEMBL22719976

O=C(C=Cc1ccccc1)c1ccccc1.O=c1ccc2ccc3occc3c2o1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 7/20 0.59
MAOA P21397 3/20 0.59
NFKB1 P19838 2/20 0.59
CYP1B1 Q16678 7/20 0.50
MAPT P10636 4/20 0.50
BCHE P06276 2/20 0.50
PLIN1 O60240 1/20 0.50
LMNA P02545 1/20 0.50
TNFRSF1A P19438 1/20 0.50
ACHE P22303 1/20 0.50
RECQL P46063 1/20 0.50
PLIN5 Q00G26 1/20 0.50
ABHD5 Q8WTS1 1/20 0.50
CA12 O43570 1/20 0.45
CA9 Q16790 1/20 0.45
CYP3A4 P08684 3/20 0.43
HSPD1 P10809 2/20 0.43
HSPE1 P61604 2/20 0.43
KMT2A Q03164 2/20 0.43
PKM P14618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chalcone SCHEMBL570745 0.78 CYP1B1 (0.61) MAOBMAOANFKB1CYP1B1MAPT
Chalcone SCHEMBL570744 0.78 CYP1B1 (0.61) MAOBMAOANFKB1CYP1B1MAPT
Angelicin SCHEMBL29468230 0.77 MAOA (1.00) MAOBMAOANFKB1CYP1B1MAPT
Angelicin SCHEMBL8726499 0.77 MAOA (1.00) MAOBMAOANFKB1CYP1B1MAPT
Angelicin SCHEMBL376379 0.77 MAOA (1.00) MAOBMAOANFKB1CYP1B1MAPT
SCHEMBL29593149 0.71 CYP3A4 (0.54) MAOBNFKB1CYP1B1MAPTBCHE
SCHEMBL28912228 0.71 CYP3A4 (0.54) MAOBNFKB1CYP1B1MAPTBCHE
Chalcone SCHEMBL27581 0.71 CYP1B1 (1.00) MAOBMAOANFKB1CYP1B1MAPT
Chalcone SCHEMBL29922932 0.71 CYP1B1 (1.00) MAOBMAOANFKB1CYP1B1MAPT
Chalcone SCHEMBL454583 0.71 CYP1B1 (1.00) MAOBMAOANFKB1CYP1B1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117679412-A Application of isopsoralen and fluconazole combined medicine in preparation of antifungal medicine 宁波市疾病预防控制中心 2024-03-12 CN disclosed
CN-117679412-A Application of isopsoralen and fluconazole combined medicine in preparation of antifungal medicine 宁波市疾病预防控制中心 2024-03-12 CN disclosed
CN-116710059-A Oral care compositions comprising hops and flavoring agents 宝洁公司 2023-09-05 CN disclosed
CN-112352887-B Compound feed for mandarin fish and preparation method thereof 广东上上生物科技有限公司 2023-06-27 CN disclosed
CN-114191427-B Medicine for inhibiting platelet activation and application thereof 黑龙江中医药大学 2022-09-02 CN disclosed
CN-114732859-A Marrow-benefiting blood-enriching pharmaceutical composition and taking method and application thereof 青海省中医院 2022-07-12 CN disclosed
CN-114191427-A Medicine for inhibiting platelet activation and application thereof 黑龙江中医药大学 2022-03-18 CN disclosed
CN-113318180-A A Chinese medicinal composition for treating traumatic injury, and its preparation method 郸城新东方骨科医院 2021-08-31 CN disclosed
CN-112816594-A Method for measuring contents of 18 chemical components in fructus psoraleae medicinal material 天津中医药大学 2021-05-18 CN disclosed
CN-112674091-A Bactericidal composition based on terpene alcohols 广东中迅农科股份有限公司 2021-04-20 CN disclosed
CN-112674089-A Terpineol-based bactericidal composition 广东中迅农科股份有限公司 2021-04-20 CN disclosed
CN-109718227-B Application of bavachalcone and isobavachalcone 中国农业科学院兰州畜牧与兽药研究所 2021-02-26 CN disclosed
WO-2020238420-A1 DRUG FOR TREATING LEUKOPENIA, PREPARATION METHOD THEREFOR AND USE THEREOF 湖北梦阳药业股份有限公司 2020-12-03 WO disclosed
CN-111588746-A Processing method of fructus psoraleae medicinal material, fructus psoraleae extract and application of fructus psoraleae extract 天津中医药大学 2020-08-28 CN disclosed
CN-111544428-A Application of isobavachalcone in preparation of hypoglycemic drugs 河南大学 2020-08-18 CN disclosed