Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL28212891 | 0.82 | RARB (0.55) | MAPK1RARBNR1H4HSD17B10MAPT | |
| SCHEMBL93241 | 0.79 | — | — | |
| SCHEMBL29227586 | 0.79 | ALDH1A1 (0.44) | MAPK1ALDH1A1CA1CA2 | |
| Propionic Acid SCHEMBL16344134 | 0.78 | FFAR3 (0.40) | MAPK1HSD17B10KDM4EALDH1A1CA1 | |
| SCHEMBL6538723 | 0.77 | MAPK1 (1.00) | MAPK1RARBKMT2ANR1H4HSD17B10 | |
| SCHEMBL1953300 | 0.77 | MAPK1 (0.65) | MAPK1RARBKMT2ATAS2R14HSD17B10 | |
| SCHEMBL29115033 | 0.77 | — | — | |
| SCHEMBL29619487 | 0.77 | GABRP (0.42) | MAPK1KMT2ATSHRCA1 | |
| SCHEMBL29096677 | 0.76 | MAPK1 (0.63) | MAPK1RARBKMT2ATAS2R14HSD17B10 | |
| SCHEMBL19475952 | 0.75 | MAPK1 (0.61) | MAPK1RARBKMT2ATAS2R14NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237772-A1 | INDUSTRIAL PREPARATION METHOD FOR ZIEGLER-NATTA CATALYST | 国家能源集团宁夏煤业有限责任公司 | 2020-12-03 | — | — | WO | disclosed |