Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592137 | 0.86 | HPGD (0.53) | HPGDALDH1A1SMN1; SMN2HTTNPC1 | |
| SCHEMBL21993 | 0.84 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL5225897 | 0.83 | NPC1 (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11745378 | 0.83 | POLB (0.65) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL392794 | 0.83 | ALDH1A1 (0.59) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4138863 | 0.83 | HPGD (0.77) | HPGDALDH1A1SMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL7764478 | 0.81 | HPGD (0.74) | HPGDALDH1A1SMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL28994974 | 0.81 | HPGD (0.74) | HPGDALDH1A1SMN1; SMN2KCNK3KCNK9 | |
| Hydrochloric Acid SCHEMBL11743648 | 0.81 | ALDH1A1 (0.58) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11750551 | 0.81 | KDR (0.54) | HPGDALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239050-A1 | 2-(2-CHLORO-4-METHYLPHENYL)QUINAZOLINE-4(3H)-KETONE COMPOUND AND MEDICAL USE THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2020-12-03 | — | — | WO | disclosed |
| CN-110041272-B | 2- (2-chlorphenyl) quinazoline-4 (3H) -ketone derivative and preparation method and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2020-10-30 | — | — | CN | disclosed |
| CN-110041273-B | 2- (2-chloro-4-methylphenyl) quinazoline-4 (3H) -ketone compound and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2020-10-20 | — | — | CN | disclosed |
| CN-110041273-A | 2- (the chloro- 4- aminomethyl phenyl of 2-) quinazoline -4 (3H) -one class compound and its medical usage | 中国人民解放军军事科学院军事医学研究院 | 2019-07-23 | — | — | CN | disclosed |
| CN-110041272-A | 2- (2- chlorphenyl) quinazoline -4 (3H) -one analog derivative and its preparation method and application | 中国人民解放军军事科学院军事医学研究院 | 2019-07-23 | — | — | CN | disclosed |