SCHEMBL22720289

SCHEMBL22720289

Cc1nc(OCC2CCCN2C)nc(N2CCN(C(=O)O)C(C(C)(C)C)C2)c1Br

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KRAS P01116 18/20 0.40
SOS1 Q07889 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22720275 0.88 KRAS (0.43) KRASSOS1
SCHEMBL28538875 0.85 KRAS (0.44) KRAS
SCHEMBL28538876 0.85 KRAS (0.44) KRAS
SCHEMBL22720277 0.83 KRAS (0.49) KRASSOS1
SCHEMBL22720270 0.82 KRAS (0.37) KRASSOS1
SCHEMBL22720285 0.79 KRAS (0.42) KRAS
SCHEMBL22720353 0.74 KRAS (0.44) KRAS
SCHEMBL22720351 0.74 KRAS (0.44) KRAS
SCHEMBL28531666 0.72 KRAS (0.45) KRASSOS1
SCHEMBL28531667 0.72 KRAS (0.45) KRASSOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020239123-A1 AROMATIC HETEROCYCLIC DERIVATIVE MODULATOR AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海翰森生物医药科技有限公司 2020-12-03 WO disclosed