Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.49 |
| ▸ | LPL | P06858 | 7/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28706226 | 0.87 | LIPG (0.51) | LIPGLPLIRAK4IDO1TDO2 | |
| SCHEMBL25822924 | 0.84 | LPL (0.49) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL25799122 | 0.83 | LIPG (0.55) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL22720360 | 0.83 | LIPG (0.51) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL18607425 | 0.81 | LPL (0.49) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL22685318 | 0.81 | LIPG (0.51) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL25668979 | 0.80 | LPL (0.50) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL27254964 | 0.80 | LIPG (0.66) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL12126755 | 0.80 | LIPG (0.47) | LIPGLPLPRMT5WDR77IRAK4 | |
| SCHEMBL29444278 | 0.79 | LPL (0.59) | LIPGLPLPRMT5WDR77IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239123-A1 | AROMATIC HETEROCYCLIC DERIVATIVE MODULATOR AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2020-12-03 | — | — | WO | disclosed |