Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | FADS1 | O60427 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10351939 | 0.79 | METAP2 (0.58) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6928574 | 0.78 | MEN1 (0.56) | NPC1ALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3559655 | 0.75 | MEN1 (0.60) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL20389106 | 0.75 | MEN1 (0.55) | GAANPC1RAB9ASMN1; SMN2PTGS1 | |
| SCHEMBL11743614 | 0.74 | NPC1 (0.72) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17744848 | 0.74 | PTGS1 (0.75) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL25142717 | 0.74 | NPC1 (0.62) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL21247272 | 0.73 | NPC1 (0.57) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL22720161 | 0.73 | HPGD (0.69) | GAAALDH1A1HSD17B10KDM4EMAPT | |
| SCHEMBL30339352 | 0.73 | NPC1 (1.00) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239050-A1 | 2-(2-CHLORO-4-METHYLPHENYL)QUINAZOLINE-4(3H)-KETONE COMPOUND AND MEDICAL USE THEREOF | 中国人民解放军军事科学院军事医学研究院 | 2020-12-03 | — | — | WO | disclosed |
| CN-110041273-B | 2- (2-chloro-4-methylphenyl) quinazoline-4 (3H) -ketone compound and medical application thereof | 中国人民解放军军事科学院军事医学研究院 | 2020-10-20 | — | — | CN | disclosed |