Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21465773 | 0.84 | CYP2D6 (0.46) | OPRM1OPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL30360515 | 0.83 | NPC1 (0.47) | L3MBTL1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL20411049 | 0.83 | NPC1 (0.47) | L3MBTL1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL15710575 | 0.77 | KDM4E (0.50) | OPRM1OPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL8034618 | 0.76 | KMT2A (0.39) | OPRM1ALDH1A1L3MBTL1CACNA1C | |
| SCHEMBL1618300 | 0.75 | NR3C1 (0.48) | OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL19778404 | 0.75 | ALDH1A1 (0.44) | OPRM1OPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL12487550 | 0.74 | ABL1 (0.45) | OPRM1OPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL20647696 | 0.74 | CYP3A4 (0.45) | OPRM1OPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL14446963 | 0.74 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851116-B2 | Bicyclic amines as novel JAK kinase inhibitors | LEO PHARMA A/S (DK) | 2020-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851116-B2 | Bicyclic amines as novel JAK kinase inhibitors | JAK1, JAK2, JAK3 | CHRM5 2691/4885CHRM1 2061/4885CHRM2 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.