Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 6/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26019654 | 0.81 | SMN1; SMN2 (0.39) | PDE3BPDE3ASMN1; SMN2CES2TP53 | |
| SCHEMBL7787350 | 0.81 | CES2 (0.47) | SMN1; SMN2CES2TP53MAPTRAB9A | |
| SCHEMBL26854405 | 0.81 | PDE3B (0.44) | PDE3BPDE3ACES2ARKIF11 | |
| SCHEMBL38659817 | 0.79 | GAA (0.52) | PDE3BPDE3ACES2MAPTALDH1A1 | |
| SCHEMBL107636 | 0.78 | CSNK2A1 (0.52) | SMN1; SMN2CES2TP53MAPTRAB9A | |
| SCHEMBL28471721 | 0.78 | CES2 (0.48) | SMN1; SMN2CES2TP53MAPTRAB9A | |
| SCHEMBL3910361 | 0.77 | KIF11 (0.42) | PDE3BPDE3ACES2ARKIF11 | |
| SCHEMBL108796 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2CES2TP53MAPTRAB9A | |
| SCHEMBL4620600 | 0.76 | CES2 (0.46) | SMN1; SMN2CES2TP53MAPTRAB9A | |
| SCHEMBL1820394 | 0.74 | CSNK2A1 (0.40) | SMN1; SMN2TP53MAPTALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243027-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SAGE THERAPEUTICS, INC. (US) | 2020-12-03 | — | — | WO | disclosed |