Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 2/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | NMT2 | O60551 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 6/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 6/20 | 0.33 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TLR2 | O60603 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4653470 | 0.84 | FURIN (0.45) | FURINFAPNMT2NMT1SIRT6 | |
| SCHEMBL4653469 | 0.84 | FURIN (0.45) | FURINFAPNMT2NMT1SIRT6 | |
| SCHEMBL468887 | 0.71 | SLC6A5 (0.54) | SIRT6SIRT1SLC6A5 | |
| SCHEMBL468889 | 0.71 | SLC6A5 (0.54) | SIRT6SIRT1SLC6A5 | |
| SCHEMBL2387748 | 0.71 | SIRT6 (0.54) | FURINSIRT6SIRT1ERAP2LNPEP | |
| SCHEMBL5494276 | 0.71 | SIRT6 (0.54) | FURINSIRT6SIRT1ERAP2LNPEP | |
| SCHEMBL27839515 | 0.70 | PAOX (0.42) | SIRT6SIRT1SLC6A5TLR2 | |
| Demannose SCHEMBL26657950 | 0.70 | FOLH1 (0.40) | NMT2NMT1SLC6A5 | |
| Galactose SCHEMBL9221802 | 0.70 | FOLH1 (0.40) | NMT2NMT1SLC6A5 | |
| SCHEMBL27846706 | 0.70 | ERAP2 (0.43) | NMT2NMT1SIRT6SIRT1SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747435-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES COMPLICATIONS COMPRISING NOVEL CHRYSIN DERIVATIVE COMPOUND AS ACTIVE INGREDIENT | FRONTBIO INC. (KR) | 2020-12-09 | — | — | EP | disclosed |
| CN-111655254-A | Pharmaceutical composition for preventing or treating diabetic complications comprising novel chrysin derivative compounds as active ingredients | 先生株式会社 | 2020-09-11 | — | — | CN | disclosed |