Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | MMP12 | P39900 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276847 | 0.93 | PRKCA (0.53) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL2278087 | 0.91 | PRKCA (0.51) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL3684086 | 0.91 | PRKCA (0.60) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL394843 | 0.90 | PRKCA (0.61) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL2280938 | 0.90 | PRKCA (0.53) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL2278545 | 0.88 | PRKCA (0.48) | PRKCAMMP12CNR2 | |
| SCHEMBL393735 | 0.86 | PRKCA (0.75) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL2277222 | 0.85 | PRKCA (0.59) | PRKCAMMP12NR1I2CYP3A4KCNH2 | |
| SCHEMBL2280880 | 0.83 | PRKCA (0.56) | PRKCAMMP12PDK1PDK2PDK3 | |
| SCHEMBL4213697 | 0.83 | PRKCA (0.57) | PRKCAMMP12PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |