Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | GHSR | Q92847 | 3/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4213697 | 0.92 | PRKCA (0.57) | PRKCAMMP12GHSRNR1I2CYP3A4 | |
| SCHEMBL2276847 | 0.91 | PRKCA (0.53) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2272958 | 0.90 | PRKCA (0.55) | PRKCAMMP12NR1I2CYP3A4PDK1 | |
| SCHEMBL2278545 | 0.89 | PRKCA (0.48) | PRKCAMMP12CNR2 | |
| SCHEMBL2274264 | 0.88 | PRKCA (0.44) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2280934 | 0.87 | PRKCA (0.51) | PRKCAMMP12GHSRNR1I2CYP3A4 | |
| SCHEMBL394843 | 0.86 | PRKCA (0.61) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2278087 | 0.86 | PRKCA (0.51) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL393735 | 0.84 | PRKCA (0.75) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2277222 | 0.83 | PRKCA (0.59) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |