Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717380 | 0.81 | KDM4E (0.50) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717735 | 0.81 | DPP4 (0.49) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL30898516 | 0.81 | KDM4E (0.50) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717307 | 0.80 | LMNA (0.46) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717257 | 0.80 | MAPT (0.47) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717520 | 0.80 | GABRP (0.51) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717419 | 0.79 | DPP4 (0.53) | LMNATP53MAPTDPP4 | |
| SCHEMBL25309295 | 0.78 | NPSR1 (0.48) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717411 | 0.78 | GABRP (0.49) | LMNATP53MAPTMEN1KMT2A | |
| SCHEMBL22717826 | 0.78 | MAPT (0.48) | LMNATP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |