Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217906 | 0.88 | PRKCA (0.67) | PRKCAMMP12SCN9AMCL1NR1I2 | |
| SCHEMBL394439 | 0.86 | PRKCA (0.57) | PRKCAMMP12SLC22A12SCN9ANR1I2 | |
| SCHEMBL392344 | 0.84 | PRKCA (0.55) | PRKCAMMP12SLC22A12SCN9ANR1I2 | |
| SCHEMBL2276308 | 0.84 | PRKCA (0.50) | PRKCAMMP12NR1I2 | |
| SCHEMBL393585 | 0.82 | PRKCA (0.68) | PRKCAMMP12SLC22A12SCN9ANR1I2 | |
| SCHEMBL2279944 | 0.82 | PRKCA (0.70) | PRKCAMMP12SLC22A12SCN9AMCL1 | |
| SCHEMBL393699 | 0.82 | PRKCA (0.70) | PRKCAMMP12SLC22A12SCN9ANR1I2 | |
| SCHEMBL391578 | 0.82 | PRKCA (0.66) | PRKCAMMP12SLC22A12SCN9ANR1I2 | |
| SCHEMBL2274540 | 0.81 | PRKCA (0.55) | PRKCAMMP12SCN9ANR1I2EGLN1 | |
| SCHEMBL2277223 | 0.80 | PRKCA (0.47) | PRKCAMMP12SCN9ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |