Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735898 | 0.90 | MAPT (0.78) | TP53MAPTLMNAPOLBALDH1A1 | |
| SCHEMBL22734680 | 0.87 | TP53 (0.80) | TP53MAPTLMNAPOLBGFER | |
| SCHEMBL22735650 | 0.85 | LMNA (0.75) | TP53MAPTLMNAPOLBALDH1A1 | |
| SCHEMBL22734792 | 0.84 | GFER (0.71) | TP53LMNAPOLBALDH1A1GFER | |
| SCHEMBL22734678 | 0.83 | LMNA (0.73) | TP53MAPTLMNAPOLBALDH1A1 | |
| SCHEMBL22734483 | 0.82 | ALDH1A1 (0.61) | TP53MAPTLMNAALDH1A1PKM | |
| SCHEMBL22734709 | 0.81 | THRB (0.72) | TP53MAPTLMNAALDH1A1GFER | |
| SCHEMBL22735810 | 0.81 | LMNA (0.62) | TP53MAPTLMNANAMPT | |
| SCHEMBL22734393 | 0.81 | LMNA (0.68) | TP53MAPTLMNAPOLBALDH1A1 | |
| SCHEMBL22400694 | 0.80 | TP53 (0.70) | TP53MAPTLMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180510-B2 | Xanthine derivatives and uses thereof as inhibitors of bromodomains of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-11-23 | — | — | US | disclosed |
| US-20200377522-A1 | XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377522-A1 | XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS | BET1, BRD4, BRD3 | TP53 1128/4885MAPT 1856/4885LMNA 2598/4885 |
| US-11180510-B2 | Xanthine derivatives and uses thereof as inhibitors of bromodomains of BET proteins | BET1, BRD4, BRD3 | TP53 1349/4885MAPT 1820/4885LMNA 2781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.