Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480741 | 1.00 | KCNJ1 (0.38) | KCNJ1GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL29480689 | 0.84 | GRM4 (0.35) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL22735911 | 0.84 | GRM4 (0.35) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL29480744 | 0.82 | LMNA (0.44) | GRM4 | |
| SCHEMBL29480720 | 0.82 | EGLN1 (0.37) | GRM4 | |
| SCHEMBL22736126 | 0.82 | EGLN1 (0.37) | GRM4 | |
| SCHEMBL22735770 | 0.79 | KMT2A (0.37) | GRM4 | |
| SCHEMBL22735754 | 0.79 | GRM4 (0.34) | GRM4 | |
| SCHEMBL22735954 | 0.79 | EGLN1 (0.34) | GRM4 | |
| SCHEMBL29567643 | 0.79 | KMT2A (0.37) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |