Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735911 | 1.00 | GRM4 (0.35) | GRM4KDM5AVHLEGLN1EGLN2 | |
| SCHEMBL22736126 | 0.87 | EGLN1 (0.37) | GRM4EGLN1 | |
| SCHEMBL29480720 | 0.87 | EGLN1 (0.37) | GRM4EGLN1 | |
| SCHEMBL29480741 | 0.84 | KCNJ1 (0.38) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL22736327 | 0.84 | KCNJ1 (0.38) | GRM4HTR2BMTNR1AKCNH2 | |
| SCHEMBL29567802 | 0.84 | EGLN1 (0.34) | GRM4EGLN1MAPT | |
| SCHEMBL29480744 | 0.83 | LMNA (0.44) | GRM4EGLN1 | |
| SCHEMBL31158291 | 0.81 | TLR7 (0.32) | GRM4EGLN1 | |
| SCHEMBL22735770 | 0.80 | KMT2A (0.37) | GRM4EGLN1NPC1MAPT | |
| SCHEMBL29480690 | 0.80 | OGA (0.34) | GRM4EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| CN-114174294-A | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2022-03-11 | — | — | CN | disclosed |