Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735925 | 0.88 | PIK3CD (0.34) | PIK3CDKDM4EEGLN1CCNCCDK8 | |
| SCHEMBL22736532 | 0.82 | JAK2 (0.35) | PIK3CDKDM4EEGLN1CXCR4RIPK2 | |
| SCHEMBL29480740 | 0.79 | TLR7 (0.34) | EGLN1GRM4JAK2JAK1RET | |
| SCHEMBL22736025 | 0.74 | NPSR1 (0.38) | EGLN1RIPK2JAK2JAK1RET | |
| SCHEMBL22736247 | 0.73 | SLC18A3 (0.35) | KDM4EEGLN1GRM4RIPK2RET | |
| SCHEMBL22735735 | 0.73 | ATR (0.34) | PIK3CDJAK2JAK1RET | |
| SCHEMBL29480746 | 0.72 | EGLN1 (0.39) | EGLN1GRM4RIPK2 | |
| SCHEMBL22736270 | 0.72 | EGLN1 (0.39) | EGLN1GRM4RIPK2 | |
| SCHEMBL22736535 | 0.69 | EGLN1 (0.42) | EGLN1GRM4 | |
| SCHEMBL29480770 | 0.69 | EGLN1 (0.42) | EGLN1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174294-B | Novel compounds for inhibiting JANUS kinase 1 | 人类制药有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-3976612-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD (IN) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |