Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22737131 | 0.88 | RIPK1 (0.52) | RIPK1SCN9AGAA | |
| SCHEMBL28714243 | 0.88 | RIPK1 (0.52) | RIPK1SCN9AGAA | |
| SCHEMBL17040899 | 0.80 | BDKRB1 (0.44) | SCN9AGAAPARP1EPHX2BDKRB1 | |
| SCHEMBL28718508 | 0.74 | RIPK1 (0.53) | RIPK1SCN9A | |
| SCHEMBL19961243 | 0.73 | PDE4B (0.41) | SCN9AGAABDKRB1 | |
| Acetic Acid SCHEMBL28780395 | 0.73 | GAA (0.40) | RIPK1SCN9AGAAPARP1EPHX2 | |
| SCHEMBL19961240 | 0.71 | CYP11B1 (0.41) | RIPK1GAAPARP1 | |
| SCHEMBL31730587 | 0.71 | AAK1 (0.39) | SCN9AGAAEPHX2BDKRB1 | |
| SCHEMBL25764042 | 0.71 | GAA (0.41) | RIPK1GAAEPHX2 | |
| SCHEMBL31552643 | 0.70 | SCN9A (0.37) | RIPK1SCN9AGAADPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239074-A1 | BICYCLIC COMPOUND AS RIP-1 KINASE INHIBITOR AND APPLICATION THEREOF | 南京明德新药研发有限公司 | 2020-12-03 | — | — | WO | disclosed |