SCHEMBL2273787

SCHEMBL2273787

CC[Si](C)(NC)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
MAPT P10636 2/20 0.33
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33
KDM4E B2RXH2 1/20 0.33
CYP3A4 P08684 1/20 0.33
TAAR1 Q96RJ0 3/20 0.32
ATM Q13315 1/20 0.32
LMNA P02545 2/20 0.32
KCNN4 O15554 2/20 0.31
CALM1 P0DP23 1/20 0.31
SLC18A2 Q05940 1/20 0.30
SIGMAR1 Q99720 1/20 0.30
CYP2D6 P10635 1/20 0.30
HTR2A P28223 1/20 0.30
HRH1 P35367 1/20 0.30
LTA4H P09960 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20499846 0.83 ESR1 (0.33) ESR1ESR2MAPTTP53TSHR
SCHEMBL2272353 0.82 ESR1 (0.35) ESR1ESR2MAPTTP53KDM4E
SCHEMBL2275514 0.75 ESR1 (0.41) ESR1ESR2MAPTTSHRKDM4E
SCHEMBL2274777 0.74 TP53 (0.35) ESR1ESR2MAPTTP53TSHR
SCHEMBL2104455 0.74 TP53 (0.40) ESR1ESR2MAPTTP53TSHR
SCHEMBL2273250 0.71 ESR1 (0.38) ESR1ESR2MAPTTP53KDM4E
SCHEMBL2104015 0.71 KDM4E (0.32) ESR1ESR2MAPTTP53TSHR
SCHEMBL7894540 0.71 ESR1 (0.34) ESR1ESR2MAPTTP53KCNN4
SCHEMBL12191013 0.70 ESR1 (0.41) ESR1ESR2MAPTTP53TSHR
SCHEMBL9226507 0.70 MAPT (0.45) ESR1ESR2MAPTTP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed