Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 19/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23720730 | 0.79 | MAP3K5 (0.36) | MAP3K5 | |
| SCHEMBL22739085 | 0.73 | MAP3K5 (0.30) | MAP3K5 | |
| SCHEMBL23721197 | 0.72 | CBLB (0.31) | MAP3K5 | |
| SCHEMBL944438 | 0.71 | MAP3K5 (0.77) | MAP3K5 | |
| SCHEMBL945206 | 0.71 | MAP3K5 (0.58) | MAP3K5 | |
| SCHEMBL22739020 | 0.70 | — | — | |
| SCHEMBL22739206 | 0.67 | MAP3K5 (0.48) | MAP3K5FLT3TYRO3MERTKGAS6 | |
| SCHEMBL23721303 | 0.66 | PIK3C3 (0.42) | MAP3K5 | |
| SCHEMBL944049 | 0.66 | MAP3K5 (0.75) | MAP3K5 | |
| SCHEMBL22739290 | 0.66 | EGFR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363797-B1 | ORAL DOSAGE FORM OF APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2020-12-02 | — | — | EP | disclosed |