Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.33 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.31 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944432 | 0.72 | FGFR3 (0.46) | DYRK1AWNT1FGFR3KDRABL1 | |
| SCHEMBL23720730 | 0.71 | MAP3K5 (0.36) | — | |
| SCHEMBL23721197 | 0.70 | CBLB (0.31) | — | |
| SCHEMBL23721171 | 0.67 | NAMPT (0.34) | DYRK1AWNT1PORCNGSK3B | |
| SCHEMBL944293 | 0.66 | LOXL2 (0.57) | DYRK1AWNT1FGFR3KDRABL1 | |
| SCHEMBL22739074 | 0.66 | MAP3K5 (0.43) | — | |
| SCHEMBL934340 | 0.65 | ABL1 (0.46) | EGFRDYRK1AWNT1KDRABL1 | |
| SCHEMBL945363 | 0.63 | MKNK1 (0.61) | PORCNWNT3A | |
| SCHEMBL30297902 | 0.63 | KMO (0.49) | PORCNWNT3A | |
| SCHEMBL946826 | 0.62 | MKNK1 (0.50) | DYRK1AABL1PORCNWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3363797-B1 | ORAL DOSAGE FORM OF APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2020-12-02 | — | — | EP | disclosed |