Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | F9 | P00740 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL947782 | 0.72 | PIK3C3 (0.51) | PIK3C3NPC1RAB9AFGFR1MKNK2 | |
| SCHEMBL23720730 | 0.67 | MAP3K5 (0.36) | PIK3C3MAP3K5 | |
| SCHEMBL22739074 | 0.66 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL945381 | 0.66 | MAP3K5 (0.68) | PIK3C3NPC1RAB9AFGFR1HPGD | |
| SCHEMBL232177 | 0.64 | MAP3K5 (0.49) | PIK3C3MAP3K5MAPT | |
| SCHEMBL23721197 | 0.61 | CBLB (0.31) | MAP3K5 | |
| SCHEMBL944268 | 0.61 | MAP3K5 (0.65) | PIK3C3HPGDMAP3K5TP53MAPT | |
| SCHEMBL945475 | 0.59 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL25901122 | 0.57 | HTT (0.59) | PIK3C3FGFR1MKNK2MKNK1 | |
| SCHEMBL23721040 | 0.56 | KDM4E (0.35) | NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858824-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |