Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279218 | 0.91 | PRKCA (0.47) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL3814277 | 0.90 | PRKCA (0.48) | PRKCAMMP12KMT2AL3MBTL1PDE4B | |
| SCHEMBL2280938 | 0.88 | PRKCA (0.53) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL2274258 | 0.85 | PRKCA (0.43) | PRKCAMMP12KMT2AL3MBTL1PDE4B | |
| SCHEMBL393733 | 0.83 | PRKCA (0.51) | PRKCAMMP12KMT2AL3MBTL1CYP2C9 | |
| SCHEMBL2960110 | 0.80 | PRKCA (0.63) | PRKCAMMP12KMT2AL3MBTL1CYP2C9 | |
| SCHEMBL4219730 | 0.80 | PRKCA (0.52) | PRKCAMMP12KMT2AHDAC1HDAC8 | |
| SCHEMBL4213697 | 0.79 | PRKCA (0.57) | PRKCAMMP12HDAC1HDAC8HDAC6 | |
| SCHEMBL2276847 | 0.79 | PRKCA (0.53) | PRKCAMMP12BRD4CYP2C9CYP3A4 | |
| SCHEMBL2278545 | 0.77 | PRKCA (0.48) | PRKCAMMP12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |