SCHEMBL2274480

SCHEMBL2274480

CCN[SiH](C)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.37
TP53 P04637 1/20 0.35
SIGMAR1 Q99720 1/20 0.33
LMNA P02545 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
MAPT P10636 2/20 0.31
GAA P10253 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CYP3A4 P08684 1/20 0.30
PSIP1 O75475 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2101040 0.83 GAA (0.33) KCNN4TP53MAPTGAAKDM4E
SCHEMBL2268660 0.78 KCNN4 (0.38) KCNN4TP53SIGMAR1LMNATDP1
SCHEMBL2102932 0.78 KCNN4 (0.38) KCNN4TP53SIGMAR1LMNATDP1
SCHEMBL10649817 0.77 MAPT (0.46) SIGMAR1TDP1MAPTGAAKDM4E
SCHEMBL2101247 0.77 CACNA2D1 (0.36) SIGMAR1MAPTKDM4E
SCHEMBL2104143 0.74 KCNN4 (0.35) KCNN4TP53SIGMAR1LMNATDP1
SCHEMBL2269967 0.74 KCNN4 (0.35) KCNN4TP53SIGMAR1LMNATDP1
SCHEMBL18143562 0.74 TSHR (0.35) KCNN4LMNATDP1
SCHEMBL2102700 0.73 KCNN4 (0.34) KCNN4TP53SIGMAR1TDP1
SCHEMBL2270141 0.72 TSHR (0.39) KCNN4SIGMAR1LMNATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed