Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GMNN | O75496 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16092091 | 0.84 | PTPN1 (0.48) | PTPN1MAPK8MAPK9MAPK10CYP1A2 | |
| SCHEMBL16092102 | 0.77 | PTPN1 (0.56) | PTPN1CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL17335809 | 0.76 | POLB (0.58) | PTPN1CYP1A2CYP3A4CYP2D6CYP1A1 | |
| SCHEMBL9956288 | 0.76 | TDP1 (0.65) | PTPN1MAPK8MAPK9MAPK10CYP1A2 | |
| SCHEMBL11713079 | 0.70 | PTPN1 (0.69) | PTPN1CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL3282190 | 0.70 | PTPN1 (0.62) | PTPN1CYP1A2CYP3A4CYP2D6CYP1A1 | |
| SCHEMBL15395615 | 0.69 | PLOD2 (0.65) | PTPN1CYP1A2CYP3A4CYP2D6CYP1A1 | |
| SCHEMBL5130621 | 0.69 | PTPN1 (0.67) | PTPN1CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL30846133 | 0.69 | PTPN1 (0.53) | PTPN1CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL5857951 | 0.69 | PTPN1 (0.71) | PTPN1CYP1A2CYP3A4CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3521284-B1 | PYRAZINE COMPOUNDS AS MAP KINASE MODULATORS AND USES THEREOF | UNIV COLUMBIA (US) | 2020-12-02 | — | — | EP | disclosed |