SCHEMBL17335809

SCHEMBL17335809

O=C(Cc1cccnc1)c1cccc2ccccc12

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.58
IDO1 P14902 4/20 0.54
NAPRT Q6XQN6 1/20 0.53
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP1A1 P04798 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP1B1 Q16678 1/20 0.52
PTPN1 P18031 1/20 0.51
MAPK1 P28482 1/20 0.50
ALDH1A1 P00352 3/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
USP2 O75604 1/20 0.48
CYP2C9 P11712 1/20 0.48
TBXAS1 P24557 1/20 0.47
KDM4E B2RXH2 1/20 0.47
LMNA P02545 1/20 0.47
HPGD P15428 1/20 0.47
TSHR P16473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16092102 0.83 PTPN1 (0.56) POLBCYP1A2CYP3A4CYP2D6PTPN1
SCHEMBL3282190 0.82 PTPN1 (0.62) POLBCYP1A2CYP3A4CYP1A1CYP2D6
SCHEMBL10696833 0.79 POLB (0.55) POLBCYP1A2CYP3A4CYP1A1CYP2D6
SCHEMBL6276675 0.79 NAPRT (0.56) IDO1NAPRTCYP1A2CYP3A4MAPK1
SCHEMBL6279379 0.79 NAPRT (0.56) IDO1NAPRTCYP1A2CYP3A4ALDH1A1
SCHEMBL15395615 0.78 PLOD2 (0.65) POLBCYP1A2CYP3A4CYP1A1CYP2D6
Bromide SCHEMBL2691231 0.78 HPGD (0.62) IDO1NAPRTCYP1A2CYP3A4ALDH1A1
SCHEMBL2473843 0.77 NAPRT (0.53) IDO1NAPRTCYP1A2CYP3A4CYP2D6
SCHEMBL16092091 0.76 PTPN1 (0.48) POLBCYP1A2CYP3A4CYP1A1CYP2D6
SCHEMBL22745166 0.76 PTPN1 (0.48) POLBCYP1A2CYP3A4CYP1A1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3845546-B1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2024-06-19 EP disclosed
EP-3842421-B1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2024-06-12 EP disclosed
US-11649258-B2 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2023-05-16 US disclosed
US-11649258-B2 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2023-05-16 US disclosed
US-11649258-B2 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2023-05-16 US disclosed
EP-3845546-A1 COMPLEXES Johnson Matthey Public Limited Company (GB) 2021-07-07 EP disclosed
EP-3845546-A1 COMPLEXES Johnson Matthey Public Limited Company (GB) 2021-07-07 EP disclosed
EP-3842421-A1 COMPLEXES Johnson Matthey Public Limited Company (GB) 2021-06-30 EP disclosed
EP-3842421-A1 COMPLEXES Johnson Matthey Public Limited Company (GB) 2021-06-30 EP disclosed
US-20210163516-A1 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2021-06-03 US disclosed
US-20190241589-A1 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2019-08-08 US disclosed
US-20190241589-A1 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2019-08-08 US disclosed
US-10253056-B2 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2019-04-09 US disclosed
US-10253056-B2 Complexes JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2019-04-09 US disclosed
US-20170121357-A1 COMPLEXES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2017-05-04 US disclosed
US-20170121357-A1 COMPLEXES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2017-05-04 US disclosed
US-20170121357-A1 COMPLEXES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2017-05-04 US disclosed
EP-3154945-A1 COMPLEXES Johnson Matthey Public Limited Company (GB) 2017-04-19 EP disclosed
WO-2015189554-A1 COMPLEXES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2015-12-17 WO disclosed
WO-2015189554-A1 COMPLEXES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2015-12-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190241589-A1 Complexes RDX, C5, RPS4X POLB 1594/4885IDO1 635/4885NAPRT 4789/4885
US-20210163516-A1 Complexes AP2M1, AP1M1, INF2 POLB 1033/4885IDO1 370/4885NAPRT 4577/4885
US-10253056-B2 Complexes CYCS, AP1M1, SOD1 POLB 233/4885IDO1 612/4885NAPRT 3959/4885
US-20170121357-A1 COMPLEXES CYCS, AP1M1, SOD1 POLB 233/4885IDO1 612/4885NAPRT 3959/4885
US-11649258-B2 Complexes AP2M1, AP1M1, INF2 POLB 1033/4885IDO1 370/4885NAPRT 4577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.