Sugi Predict

Sugi Predict / Compounds / SCHEMBL3282190

SCHEMBL3282190

SCHEMBL3282190

O=C(Cc1ccccc1)c1cccc2ccccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTPN1 P18031 1/20 0.62
▸ NR4A1 P22736 1/20 0.60
▸ NR4A2 P43354 1/20 0.60
▸ NR4A3 Q92570 1/20 0.60
▸ ALDH1A1 P00352 5/20 0.58
▸ HPGD P15428 4/20 0.58
▸ KDM4E B2RXH2 4/20 0.58
▸ MAPT P10636 4/20 0.58
▸ LMNA P02545 3/20 0.58
▸ TDP1 Q9NUW8 3/20 0.58
▸ MEN1 O00255 3/20 0.58
▸ KMT2A Q03164 3/20 0.58
▸ GMNN O75496 2/20 0.58
▸ POLB P06746 2/20 0.58
▸ MAPK1 P28482 2/20 0.58
▸ BLM P54132 2/20 0.58
▸ PMP22 Q01453 2/20 0.58
▸ NPSR1 Q6W5P4 2/20 0.58
▸ CMKLR1 Q99788 2/20 0.58
▸ TP53 P04637 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16171213 0.88 NPC1 (0.63) PTPN1NR4A1NR4A2NR4A3ALDH1A1
SCHEMBL16092102 0.86 PTPN1 (0.56) PTPN1NR4A1NR4A2NR4A3ALDH1A1
SCHEMBL29170941 0.84 KDM4E (0.57) PTPN1NR4A1NR4A2NR4A3ALDH1A1
SCHEMBL6515385 0.82 HPGD (0.52) PTPN1NR4A1NR4A2NR4A3ALDH1A1
SCHEMBL17335809 0.82 POLB (0.58) PTPN1ALDH1A1HPGDKDM4ELMNA
SCHEMBL6515393 0.82 HPGD (0.52) PTPN1NR4A1NR4A2NR4A3ALDH1A1
SCHEMBL7064650 0.82 PTPN1 (0.51) PTPN1NR4A1NR4A2NR4A3ALDH1A1
SCHEMBL16162267 0.82 TP53 (0.67) PTPN1ALDH1A1HPGDKDM4EMAPT
SCHEMBL7129795 0.82 MEN1 (0.62) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL9956288 0.81 TDP1 (0.65) PTPN1NR4A1NR4A2NR4A3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999042466-A2 β-LACTAM-LIKE CHAPERONE INHIBITORS WASHINGTON UNIVERSITY (US) 1999-08-26 — — WO claimed
JP-61000031-A — — None — — JP disclosed
US-20160311785-A1 TRIAZINE MEDIATED LIVING RADICAL CONTROLLED POLYMERIZATION DOW GLOBAL TECHNOLOGIES LLC 2016-10-27 — — US disclosed
US-9283229-B2 Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors NIVALIS THERAPEUTICS, INC. (US) 2016-03-15 — — US disclosed
US-20150224107-A1 Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors N30 PHARMACEUTICALS, LLC 2015-08-13 — — US disclosed
US-9067893-B2 Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors NIVALIS THERAPEUTICS, INC. (US) 2015-06-30 — — US disclosed
US-20140235640-A1 Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors N30 PHARMACEUTICALS, INC. (US) 2014-08-21 — — US disclosed
US-8741915-B2 Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors N30 PHARMACEUTICALS, INC. (US) 2014-06-03 — — US disclosed
EP-2018364-B1 THERAPEUTIC FLUOROETHYL UREAS ALLERGAN INC (US) 2013-08-21 — — EP disclosed
US-20120208817-A1 Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors N30 PHARMACEUTICALS, LLC (US) 2012-08-16 — — US disclosed
EP-0753540-B1 Polycarbonate resin composition MITSUBISHI ENG PLASTICS CORP (JP) 2003-06-11 — — EP disclosed
US-6359028-B1 USED IN MEDICAL EQUIPMENT, DISCOLORATION INHIBITION MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 2002-03-19 — — US disclosed
US-20010034419-A1 Radiation transparent molding materials MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 2001-10-25 — — US disclosed
US-6040367-A EXCELLENT RESISTANCE TO AN IONIZING RADIATION, IN WHICH HETEROCYCLIC COMPOUND CONTAINING OXYMETHYLENE UNITS MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 2000-03-21 — — US disclosed
US-5977206-A Polycarbonate resin composition MITSUBISHI ENGINEERING-PLASTICS CORP. (JP) 1999-11-02 — — US disclosed
US-5948838-A 0.01 TO 5 PARTS BY WEIGHT OF A COMPOUND CONTAINING OXYMETHYLENE UNIT MITSUBISHI ENGINEERING-PLASTICS CORP. (JP) 1999-09-07 — — US disclosed
WO-1999042466-A2 β-LACTAM-LIKE CHAPERONE INHIBITORS WASHINGTON UNIVERSITY (US) 1999-08-26 — — WO disclosed
EP-0794218-A2 Polycarbonate resin composition stabilized against radiation MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 1997-09-10 — — EP disclosed
EP-0753540-A2 Polycarbonate resin composition MITSUBISHI ENGINEERING-PLASTICS CORPORATION (JP) 1997-01-15 — — EP disclosed
JP-S6131-A NAPHTHALENE DERIVATIVE CHISSO CORP 1986-01-06 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140235640-A1 Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors QDPR, GSR, CBR1 PTPN1 2141/4885NR4A1 1478/4885NR4A2 891/4885
US-20120208817-A1 Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors QDPR, GSR, CBR1 PTPN1 2141/4885NR4A1 1478/4885NR4A2 891/4885
US-20150224107-A1 Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors QDPR, GSR, CBR1 PTPN1 2141/4885NR4A1 1478/4885NR4A2 891/4885
US-20160311785-A1 TRIAZINE MEDIATED LIVING RADICAL CONTROLLED POLYMERIZATION ROS1, MTR, CYBB PTPN1 2043/4885NR4A1 2070/4885NR4A2 1466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.