Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19897164 | 0.88 | RIPK1 (0.48) | NPSR1MAPTLMNAGPR119L3MBTL1 | |
| SCHEMBL2545923 | 0.88 | USP30 (0.47) | NPSR1MAPTLMNAL3MBTL1GRM5 | |
| SCHEMBL19897161 | 0.88 | RIPK1 (0.48) | NPSR1MAPTLMNAGPR119L3MBTL1 | |
| SCHEMBL31306998 | 0.88 | RIPK1 (0.48) | NPSR1MAPTLMNAGPR119L3MBTL1 | |
| SCHEMBL19897159 | 0.88 | RIPK1 (0.48) | NPSR1MAPTLMNAGPR119L3MBTL1 | |
| SCHEMBL6012032 | 0.87 | MEN1 (0.53) | NPSR1LMNAGPR119L3MBTL1MEN1 | |
| SCHEMBL3052925 | 0.87 | MEN1 (0.53) | NPSR1LMNAGPR119L3MBTL1MEN1 | |
| SCHEMBL3052928 | 0.87 | MEN1 (0.53) | NPSR1LMNAGPR119L3MBTL1MEN1 | |
| SCHEMBL19935193 | 0.85 | NPC1 (0.42) | NPSR1MAPTLMNAL3MBTL1MEN1 | |
| SCHEMBL7487281 | 0.81 | GPR119 (0.47) | NPSR1MAPTLMNAGPR119L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504214-B1 | FUSED TRICYCLIC PYRIDAZINONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2020-12-02 | — | — | EP | disclosed |