Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16835743 | 0.83 | HPGD (0.63) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL7925431 | 0.81 | L3MBTL1 (0.54) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL11544150 | 0.81 | MEN1 (0.58) | HPGDLMNAALDH1A1RAB9ANPC1 | |
| SCHEMBL1264964 | 0.80 | LMNA (0.64) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL12465718 | 0.79 | L3MBTL1 (0.56) | HPGDLMNAKDM4EGAAL3MBTL1 | |
| SCHEMBL29473477 | 0.78 | LMNA (0.62) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL13332620 | 0.78 | KDM4E (0.55) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL28938376 | 0.78 | LMNA (0.62) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL15397091 | 0.77 | KDM4E (0.50) | HPGDLMNAKDM4EALDH1A1GAA | |
| SCHEMBL28723696 | 0.77 | KDM4E (0.50) | HPGDLMNAKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244637-A1 | TRICYCLIC COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-12-10 | — | — | WO | disclosed |