Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760486 | 0.91 | FOLH1 (0.43) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22748283 | 0.90 | FOLH1 (0.42) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22748245 | 0.90 | FOLH1 (0.42) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22760136 | 0.89 | NPSR1 (0.59) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22747833 | 0.88 | FOLH1 (0.41) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22760554 | 0.87 | FOLH1 (0.40) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22747897 | 0.87 | FOLH1 (0.40) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22760555 | 0.86 | FOLH1 (0.39) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22760356 | 0.82 | MAT2A (0.43) | MAPK8MAPK9NPSR1HTTALDH1A1 | |
| SCHEMBL22760225 | 0.79 | FOLH1 (0.44) | MAPK8MAPK9ALDH1A1GAAFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |