Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 5/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760049 | 0.92 | EDNRA (0.40) | NOTUMTHRBEDNRACCR2KDM4E | |
| SCHEMBL22760158 | 0.89 | NOTUM (0.41) | NOTUMEDNRAALDH1A1KMT2AMEN1 | |
| SCHEMBL22760426 | 0.88 | EDNRA (0.39) | EDNRACCR2KDM4EALDH1A1KMT2A | |
| SCHEMBL22760364 | 0.87 | FOLH1 (0.37) | NOTUMEDNRACCR2ALDH1A1KMT2A | |
| SCHEMBL22760144 | 0.84 | RPA1 (0.36) | NOTUMEDNRACCR2KDM4EKMT2A | |
| SCHEMBL22747838 | 0.84 | NOTUM (0.42) | NOTUMTHRBEDNRAKDM4EALDH1A1 | |
| SCHEMBL22747882 | 0.81 | HTT (0.37) | NOTUMCCR2KMT2AMEN1HPGD | |
| SCHEMBL22747843 | 0.81 | MAPK8 (0.40) | NOTUMTHRBEDNRAALDH1A1KMT2A | |
| SCHEMBL22760379 | 0.80 | SMN1; SMN2 (0.35) | NOTUMALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL22747829 | 0.79 | FOLH1 (0.35) | NOTUMTHRBEDNRAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |