Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22760364 | 0.88 | FOLH1 (0.37) | CCR2NOTUMSMN1; SMN2LMNAMAPT | |
| SCHEMBL22760158 | 0.86 | NOTUM (0.41) | NOTUMLMNARORCKMT2AEDNRA | |
| SCHEMBL22748255 | 0.84 | NOTUM (0.41) | CCR2NOTUMKDM4EKMT2AEDNRB | |
| SCHEMBL22760373 | 0.84 | FOLH1 (0.36) | RPA1CCR2NOTUMKDM4ENPC1 | |
| SCHEMBL22760379 | 0.83 | SMN1; SMN2 (0.35) | RPA1CTSBTDP1NOTUMNPC1 | |
| SCHEMBL22760426 | 0.83 | EDNRA (0.39) | RPA1CCR2KDM4ENPC1MAPT | |
| SCHEMBL22747882 | 0.82 | HTT (0.37) | CTSBTDP1CCR2NOTUMSMN1; SMN2 | |
| SCHEMBL22760068 | 0.82 | CENPE (0.38) | TDP1CCR2NOTUMKDM4ESMN1; SMN2 | |
| SCHEMBL22747829 | 0.80 | FOLH1 (0.35) | NOTUMSMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL22760127 | 0.79 | NOTUM (0.37) | CCR2NOTUMKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |