Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15004205 | 0.79 | NISCH (0.38) | NISCHCHRNB4CHRNA3NR1I2ADORA3 | |
| SCHEMBL11317588 | 0.74 | MAOA (0.36) | NISCHCHRNB4CHRNA3TSHRMAPK10 | |
| SCHEMBL2282129 | 0.74 | NISCH (0.44) | NISCHCHRNB4CHRNA3GAATSHR | |
| SCHEMBL28474885 | 0.70 | CHRNB4 (0.52) | NISCHCHRNB4CHRNA3GAATSHR | |
| SCHEMBL6810811 | 0.64 | ALDH1A1 (0.44) | NISCHCHRNB4CHRNA3GAATSHR | |
| SCHEMBL28854031 | 0.62 | ALDH1A1 (0.36) | TSHRALDH1A1MAPK1BACE1 | |
| SCHEMBL12992395 | 0.62 | HSD17B10 (0.39) | GAATSHRADORA3ALDH1A1MAPK1 | |
| SCHEMBL31497105 | 0.61 | ALDH1A1 (0.47) | HTR2CALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL2616795 | 0.61 | L3MBTL1 (0.37) | NISCHCHRNB4CHRNA3ALDH1A1GABRA1 | |
| SCHEMBL24863008 | 0.60 | HSD17B10 (0.36) | TSHRADORA3ALDH1A1MAPK1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7993494-B2 | Method for manufacturing triarylpyrazine derivative | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-08-09 | — | — | US | disclosed |