Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3046343 | 0.84 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRNPC1KDM4E | |
| SCHEMBL22750819 | 0.80 | HPGD (0.46) | ALDH1A1HPGDL3MBTL1TSHRNPC1 | |
| SCHEMBL3045369 | 0.79 | RAB9A (0.59) | ALDH1A1HPGDL3MBTL1TSHRNPC1 | |
| SCHEMBL25294798 | 0.72 | L3MBTL1 (0.68) | ALDH1A1HPGDL3MBTL1TSHRNPC1 | |
| SCHEMBL22750815 | 0.72 | ALDH1A1 (0.53) | ALDH1A1HPGDTSHRNPC1KDM4E | |
| SCHEMBL244627 | 0.70 | ALDH1A1 (0.72) | ALDH1A1HPGDTSHRNPC1KDM4E | |
| SCHEMBL8556695 | 0.70 | L3MBTL1 (0.73) | ALDH1A1HPGDL3MBTL1TSHRNPC1 | |
| SCHEMBL20888390 | 0.69 | ALDH1A1 (0.70) | ALDH1A1HPGDTSHRNPC1KDM4E | |
| SCHEMBL349175 | 0.69 | ALDH1A1 (0.68) | ALDH1A1HPGDTSHRNPC1KDM4E | |
| SCHEMBL2208204 | 0.68 | ALDH1A1 (0.72) | ALDH1A1HPGDTSHRNPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |