Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.57 |
| ▸ | JAK2 | O60674 | 9/20 | 0.57 |
| ▸ | JAK3 | P52333 | 9/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.57 |
| ▸ | IKBKB | O14920 | 7/20 | 0.57 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | TYK2 | P29597 | 5/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524962 | 0.84 | ROCK2 (0.61) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL20524963 | 0.84 | ROCK2 (0.61) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL22752066 | 0.81 | JAK3 (0.66) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL21845793 | 0.81 | JAK2 (0.48) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL22752242 | 0.80 | ROCK2 (0.59) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL22752041 | 0.79 | ROCK2 (0.53) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL23633801 | 0.79 | ROCK2 (0.60) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL23633806 | 0.79 | ROCK2 (0.60) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL22857543 | 0.78 | ROCK2 (0.62) | ROCK2JAK2JAK3ROCK1IKBKB | |
| SCHEMBL22752138 | 0.78 | ROCK2 (0.62) | ROCK2JAK2JAK3ROCK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018012-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230130470-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | ALCON INC. (CH) | 2023-04-27 | — | — | US | disclosed |
| US-11312700-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210002253-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | ALCON INC. (CH) | 2021-01-07 | — | — | US | disclosed |
| US-10858339-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | AERIE PHARMACEUTICALS, INC. (US) | 2020-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002253-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | UACA, HRAS, MYLK | ROCK2 219/4885JAK2 268/4885JAK3 653/4885 |
| US-12018012-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | UACA, HRAS, MYLK | ROCK2 219/4885JAK2 268/4885JAK3 653/4885 |
| US-11312700-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | UACA, HRAS, MYLK | ROCK2 219/4885JAK2 268/4885JAK3 653/4885 |
| US-10858339-B2 | Aryl cyclopropyl-amino-isoquinolinyl amide compounds | UACA, HRAS, MYLK | ROCK2 219/4885JAK2 268/4885JAK3 653/4885 |
| US-20230130470-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | UACA, HRAS, MYLK | ROCK2 219/4885JAK2 268/4885JAK3 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.