Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22068306 | 0.84 | LMNA (0.31) | KDM4E | |
| SCHEMBL1844564 | 0.77 | PRMT3 (0.42) | CYP2C9CYP2C19ANPEPKDM4E | |
| SCHEMBL22123554 | 0.77 | PRMT3 (0.42) | — | |
| SCHEMBL23789494 | 0.73 | — | — | |
| SCHEMBL13792972 | 0.71 | KDM4E (0.53) | KDM4E | |
| SCHEMBL29460411 | 0.70 | MCL1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL8984856 | 0.70 | AOC3 (0.38) | — | |
| SCHEMBL23789495 | 0.70 | CA12 (0.48) | CYP2C9CYP2C19KDM4E | |
| SCHEMBL18743852 | 0.69 | — | — | |
| SCHEMBL14542570 | 0.68 | KDM4E (0.45) | CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858360-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858360-B2 | Tricyclic gyrase inhibitors | TOP1, TOP2A, TOP2B | CYP2C9 52/4885CYP2C19 33/4885ANPEP 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.