Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2275286 | 0.81 | SMN1; SMN2 (0.55) | HRH1HRH2SMN1; SMN2MYCLMNA | |
| SCHEMBL7235994 | 0.81 | CAPN1 (0.51) | CHIAOPRD1OPRK1 | |
| SCHEMBL7235995 | 0.81 | CAPN1 (0.47) | KMT2ACHIAOPRD1OPRK1MEN1 | |
| SCHEMBL7235600 | 0.79 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1NPC1GAA | |
| SCHEMBL3668350 | 0.79 | LMNA (0.47) | KMT2ATRPA1OPRD1OPRK1MEN1 | |
| SCHEMBL4554527 | 0.79 | POLB (0.61) | KMT2ATRPA1TRPV1MYCPOLB | |
| SCHEMBL27470853 | 0.79 | HRH4 (0.53) | KMT2AOPRD1OPRK1MEN1POLB | |
| SCHEMBL31635760 | 0.78 | SMN1; SMN2 (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL3693484 | 0.78 | SMN1; SMN2 (0.49) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1459682 | 0.76 | MAPT (0.57) | KMT2AMEN1HRH1HRH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |