Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 17/20 | 0.44 |
| ▸ | DLK1 | P80370 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAP3K13 | O43283 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22723567 | 1.00 | MAP3K12 (0.44) | MAP3K12DLK1LRRK2MAP3K13 | |
| SCHEMBL22723429 | 1.00 | MAP3K12 (0.44) | MAP3K12DLK1LRRK2MAP3K13 | |
| SCHEMBL20437510 | 0.89 | MAP3K12 (0.35) | MAP3K12DLK1LRRK2MAP3K13 | |
| SCHEMBL20437623 | 0.86 | MAP3K12 (0.45) | MAP3K12DLK1LRRK2MAP3K13 | |
| SCHEMBL22753144 | 0.83 | MAP3K12 (0.46) | MAP3K12DLK1MAP3K13 | |
| SCHEMBL22723461 | 0.83 | MAP3K12 (0.46) | MAP3K12DLK1MAP3K13 | |
| SCHEMBL22723456 | 0.83 | MAP3K12 (0.46) | MAP3K12DLK1MAP3K13 | |
| SCHEMBL22753158 | 0.81 | MAP3K12 (0.45) | MAP3K12DLK1MAP3K13 | |
| SCHEMBL22723556 | 0.81 | MAP3K12 (0.45) | MAP3K12DLK1MAP3K13 | |
| SCHEMBL22723585 | 0.81 | MAP3K12 (0.45) | MAP3K12DLK1MAP3K13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858367-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858367-B2 | Compounds | LRRK2, PARK7, PINK1 | MAP3K12 69/4885DLK1 1704/4885LRRK2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.