SCHEMBL2275321

SCHEMBL2275321

CC(C)[SiH](CCCN(C)C)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 4/20 0.46
HRH1 P35367 4/20 0.46
SIGMAR1 Q99720 1/20 0.42
TAAR1 Q96RJ0 1/20 0.38
LSS P48449 1/20 0.38
LMNA P02545 3/20 0.36
CYP1A2 P05177 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
ADRA2A P08913 1/20 0.36
CYP2D6 P10635 1/20 0.36
CHRM1 P11229 1/20 0.36
TSHR P16473 1/20 0.36
ADRA2B P18089 1/20 0.36
CHRM3 P20309 1/20 0.36
SLC6A2 P23975 1/20 0.36
HRH2 P25021 1/20 0.36
HTR2C P28335 1/20 0.36
SLC6A4 P31645 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273389 0.83 SIGMAR1 (0.49) HTR2AHRH1SIGMAR1LMNACYP1A2
SCHEMBL27614153 0.79 LTA4H (0.33) HTR2ASIGMAR1SMN1; SMN2
SCHEMBL2271824 0.78 TRPA1 (0.31) HTR2AHRH1CYP1A2CHRM2ADRA2A
SCHEMBL2275572 0.75 HRH1 (0.46) HTR2AHRH1SIGMAR1TAAR1LMNA
SCHEMBL2273433 0.70 HTR2A (0.41) HTR2AHRH1SIGMAR1TAAR1LSS
SCHEMBL8344995 0.70 TP53 (0.35) HTR2ASIGMAR1TAAR1LMNATSHR
SCHEMBL2100897 0.69 SIGMAR1 (0.47) HTR2AHRH1SIGMAR1TAAR1LSS
SCHEMBL10320035 0.69 TAAR1 (0.37) HTR2ASIGMAR1TAAR1LMNACYP2D6
SCHEMBL2272371 0.67 HTR2A (0.42) HTR2AHRH1SIGMAR1TAAR1LMNA
SCHEMBL2104136 0.66 TAAR1 (0.43) HTR2AHRH1SIGMAR1TAAR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404584-B2 Method of manufacturing semiconductor device FUJITSU LIMITED (JP) 2013-03-26 US disclosed
US-20110207319-A1 METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE FUJITSU LIMITED (JP) 2011-08-25 US disclosed