SCHEMBL22754271

SCHEMBL22754271

CNNC(=O)OCCOCCOCCOCCN

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.33
CHRNA4 P43681 2/20 0.33
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM5 P08912 1/20 0.33
CYP2D6 P10635 1/20 0.33
CHRM1 P11229 1/20 0.33
NFKB1 P19838 1/20 0.33
CHRM3 P20309 1/20 0.33
MAPK1 P28482 1/20 0.33
CHRNA7 P36544 1/20 0.33
ACHE P22303 1/20 0.33
ALDH1A1 P00352 3/20 0.32
TSHR P16473 3/20 0.32
TP53 P04637 2/20 0.32
HIF1A Q16665 2/20 0.32
LMNA P02545 1/20 0.32
APEX1 P27695 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
EPHX1 P07099 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20662244 1.00 CHRNB2 (0.33) CHRNB2CHRNA4CHRM2CHRM4CHRM5
SCHEMBL20662273 1.00 CHRNB2 (0.33) CHRNB2CHRNA4CHRM2CHRM4CHRM5
SCHEMBL28453692 0.84 CHRNB2 (0.48) CHRNB2CHRNA4CHRM2CHRM4CHRM5
SCHEMBL30380366 0.84 CHRNB2 (0.48) CHRNB2CHRNA4CHRM2CHRM4CHRM5
SCHEMBL21070274 0.84 CHRNB2 (0.48) CHRNB2CHRNA4CHRM2CHRM4CHRM5
SCHEMBL21071251 0.84 CHRNB2 (0.48) CHRNB2CHRNA4CHRM2CHRM4CHRM5
SCHEMBL22754196 0.82 ALDH1A1 (0.33) ACHEALDH1A1TSHRTP53HIF1A
SCHEMBL22754259 0.82 ALDH1A1 (0.33) ACHEALDH1A1TSHRTP53HIF1A
SCHEMBL22754221 0.82 ALDH1A1 (0.33) ACHEALDH1A1TSHRTP53HIF1A
SCHEMBL21207371 0.81 ALDH1A1 (0.32) ALDH1A1TSHRTP53HIF1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3099681-B1 CYTOTOXIC TUBULYSIN COMPOUNDS AND CONJUGATES THEREOF TUBE PHARMACEUTICALS GMBH (AT) 2020-12-09 EP disclosed