Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21171631 | 0.84 | HDAC6 (0.47) | SYKHDAC6HDAC3KDRHDAC2 | |
| SCHEMBL21167474 | 0.83 | SYK (0.48) | SYKHDAC6HDAC3KDRHDAC2 | |
| SCHEMBL24067916 | 0.83 | HDAC6 (0.46) | SYKHDAC6HDAC3ARHDAC2 | |
| SCHEMBL24067886 | 0.83 | HDAC6 (0.44) | SYKHDAC6HDAC3HDAC2HDAC1 | |
| SCHEMBL22754358 | 0.82 | SYK (0.47) | SYKHDAC6HDAC3KDR | |
| SCHEMBL21167638 | 0.82 | SYK (0.46) | SYKHDAC6HDAC3KDRPDPK1 | |
| SCHEMBL22754396 | 0.82 | L3MBTL1 (0.51) | SYKHDAC6HTTHDAC1ALDH1A1 | |
| SCHEMBL22754380 | 0.82 | MET (0.51) | SYKHDAC6HDAC3KDRHDAC1 | |
| SCHEMBL22754415 | 0.82 | MET (0.42) | SYKHDAC6HDAC3KDRPDPK1 | |
| SCHEMBL21167387 | 0.81 | SYK (0.48) | SYKHDAC3KDRFLT1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831073-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES | RHIZEN PHARMACEUTICALS S A (CH) | 2020-12-09 | — | — | EP | disclosed |