Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TET3 | O43151 | 1/20 | 0.51 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.51 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 6/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754398 | 0.91 | L3MBTL1 (0.49) | L3MBTL1KDM4ETET3TET2TET1 | |
| SCHEMBL21171631 | 0.90 | HDAC6 (0.47) | KDM4ESYKALDH1A1HDAC6HDAC1 | |
| SCHEMBL24067916 | 0.87 | HDAC6 (0.46) | SYKHDAC6HDAC1CYP3A4 | |
| SCHEMBL24067886 | 0.86 | HDAC6 (0.44) | SYKHDAC6HDAC1MET | |
| SCHEMBL21171387 | 0.83 | MAP4K4 (0.49) | IKBKBMAPTHDAC6MAP4K4MET | |
| SCHEMBL21171652 | 0.83 | MAP4K4 (0.48) | IKBKBMAPTMAP4K4METCHUK | |
| SCHEMBL22754334 | 0.82 | SYK (0.46) | SYKALDH1A1HTTSMN1; SMN2HDAC6 | |
| SCHEMBL21171382 | 0.79 | IKBKB (0.45) | SYKIKBKBHDAC6PRMT1HDAC1 | |
| SCHEMBL21172009 | 0.79 | MET (0.47) | SYKMET | |
| SCHEMBL1328548 | 0.78 | MET (0.51) | L3MBTL1KDM4ETET3TET2TET1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831073-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES | RHIZEN PHARMACEUTICALS S A (CH) | 2020-12-09 | — | — | EP | disclosed |