Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | RAF1 | P04049 | 6/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754650 | 0.90 | KDR (0.43) | CCNCCDK8KDRRAF1BRAF | |
| SCHEMBL18808807 | 0.77 | KDR (0.52) | CCNCCDK8KDRRAF1BRAF | |
| SCHEMBL13300975 | 0.74 | KDR (0.76) | CCNCCDK8KDRRAF1BRAF | |
| SCHEMBL22754641 | 0.72 | CCNC (0.54) | CCNCCDK8KDRRAF1BRAF | |
| SCHEMBL26547019 | 0.72 | ALDH1A1 (0.40) | KDRRAF1BRAFEPHX2PDGFRB | |
| SCHEMBL14009092 | 0.72 | CCNC (0.56) | CCNCCDK8KDRRAF1BRAF | |
| SCHEMBL19678074 | 0.71 | SAE1 (0.56) | CCNCCDK8KDRRAF1MEN1 | |
| SCHEMBL14793109 | 0.69 | CYP3A4 (0.42) | MAPK14CSF1RRIPK1 | |
| SCHEMBL17109651 | 0.69 | RAF1 (0.82) | CCNCCDK8KDRRAF1BRAF | |
| SCHEMBL24975884 | 0.68 | CCNC (1.00) | CCNCCDK8RAF1MAPK14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747433-A1 | COMBINATION OF CELLULAR IMMUNOTHERAPY | Carsgen Therapeutics Co., Ltd. (CN) | 2020-12-09 | — | — | EP | disclosed |