Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22729511 | 0.89 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL29839337 | 0.89 | MAPT (0.50) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL22729506 | 0.84 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL22754983 | 0.76 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL22755057 | 0.75 | MAPT (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL22755013 | 0.68 | CD38 (0.34) | KDM4E | |
| SCHEMBL22729533 | 0.65 | MAPT (0.42) | MAPTTP53TSHRKDM4EGAA | |
| SCHEMBL5934793 | 0.64 | MAPT (0.63) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL29839342 | 0.64 | KMT2A (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1DGAT1 | |
| SCHEMBL22729543 | 0.64 | BRD4 (0.44) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3747885-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2020-12-09 | — | — | EP | disclosed |